stimulation of type i collagen activity in healing of pulp perforation
Clicks: 254
ID: 156123
2008
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
9.6
/100
32 views
32 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Background: TGF-β1 is a connective tissue stimulant, potential regulator for tissue repair, and promoter in wound healing. The healing of pulp perforation is decided by quantity and quality of new collagen deposition. TGF-β1 upregulates collagen transcription. However, after several weeks production of type I collagen synthesis is stopped and enzymatic degradation of collagen matrix will occur. Purpose: Observe synthesis type I collagen during the process of pulp perforation healing in 7, 14, and 21 days after being treated using TGF-β1. Methods: This research in vivo from orthodontic patients indicated for premolar extraction, between ages 10–15 years. A class V cavity preparation was created in the buccal aspect 1 mm above gingival margin until pulp exposure. Cavity was irrigated slowly with saline solution and dried with a sterile small cotton pellet. The sterile absorbable collagen membrane used, soaked with 5 μl of TGF-β1. It was covered by teflon pledge to separate from glass ionomer cement as restoration. Evaluated on day 7th, 14th, and 21st. All samples were extracted and prepared for immunohystochemical examination. Result: Data were analyzed by t-test. There was significant difference in synthesis type I collagen compared between 7–14 days and 7–21 days after treatment by TGF-β1 also Ca(OH)2. There was significant difference compared between TGF-β1 and Ca(OH)2 in 14–21 days after treatment (means TGF-β1 > Ca(OH)2). Conclusion: Elevation of synthesis type 1 collagen by TGF-β1 in 20 mg/ml.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (223 words).
Try re-searching for a better abstract.
| Reference Key |
kunarti2008dentalstimulation
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Sri Kunarti |
| Journal | industrial crops and products |
| Year | 2008 |
| DOI |
10.20473/j.djmkg.v41.i4.p182-185
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.