reducing x-ray induced oxidative damages in fibroblasts with graphene oxide

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ID: 156090
2014
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Ranked #35 of 133 articles by views in progress in neuro-psychopharmacology & biological psychiatry

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Abstract
A major issue of X-ray radiation therapy is that normal cells can be damaged, limiting the amount of X-rays that can be safely delivered to a tumor. This paper describes a new method based on graphene oxide (GO) to protect normal cells from oxidative damage by removing free radicals generated by X-ray radiation using grapheme oxide (GO). A variety of techniques such as cytotoxicity, genotoxicity, oxidative assay, apoptosis, γ-H2AX expression, and micro-nucleus assay have been used to assess the protective effect of GO in cultured fibroblast cells. It is found that although GO at higher concentration (100 and 500 µg/mL) can cause cell death and DNA damage, it can effectively remove oxygen free radicals at a lower concentration of 10 µg/mL. The level of DNA damage and cell death is reduced by 48%, and 39%, respectively. Thus, low concentration GO can be used as an effective radio-protective agent in occupational and therapeutic settings.
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qiao2014nanomaterialsreducing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yong Qiao;Peipei Zhang;Chaoming Wang;Liyuan Ma;Ming Su
Journal progress in neuro-psychopharmacology & biological psychiatry
Year 2014
DOI
10.3390/nano4020522
URL
http://www.mdpi.com/2079-4991/4/2/522
Keywords
graphene oxide dna damage oxidative reactive oxygen species (ros)chemistry

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