correlation of serum cystatin c with glomerular filtration rate in patients receiving platinum-based chemotherapy

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ID: 155573
2016
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Abstract
Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. Serum creatinine was assayed on Cobas C6000-Roche, serum cystatin C assay was performed on AIA 360-Tosoh, and GFR was determined in all patients, before the first cycle of chemotherapy and before the subsequent administrations. Results. In the overall series, for the prediction of a fall of GFR < 80 mL/min/1.73 m2, the AUC of the ROC curve for cystatin C was 0,667 and the best threshold was 1.135 mg/L (sensitivity 90.5%, specificity 61.1%). For a GFR fall < 60 mL/min/1.73 m2, the AUC of ROC curve for cystatin C was 74.3% and the best threshold was 1.415 mg/L (sensitivity 66.7%, specificity 73.2%). Conclusions. Baseline cystatin C values were not able to predict renal failure during subsequent treatment. In conclusion, serum cystatin C is not a reliable early marker to efficiently predict renal failure in patients receiving chemotherapy.
Reference Key
cavalcanti2016analyticalcorrelation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ernesta Cavalcanti;Vittoria Barchiesi;Dionigio Cerasuolo;Flaviano Di Paola;Monica Cantile;Sabrina Chiara Cecere;Sandro Pignata;Alessandro Morabito;Raffaele Costanzo;Massimo Di Maio;Francesco Perrone
Journal oriente moderno
Year 2016
DOI
10.1155/2016/4918325
URL
http://dx.doi.org/10.1155/2016/4918325
Keywords
neoplasms Oncology including cancer and carcinogenscytology tumors

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