The global spread of HIV-1 subtype B epidemic.

Clicks: 227
ID: 15517
2016
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Ranked #24 of 61 articles by views in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

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Abstract
Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors.
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magiorkinis2016theinfection Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Magiorkinis, Gkikas;Angelis, Konstantinos;Mamais, Ioannis;Katzourakis, Aris;Hatzakis, Angelos;Albert, Jan;Lawyer, Glenn;Hamouda, Osamah;Struck, Daniel;Vercauteren, Jurgen;Wensing, Annemarie;Alexiev, Ivailo;Åsjö, Birgitta;Balotta, Claudia;Gomes, Perpétua;Camacho, Ricardo J;Coughlan, Suzie;Griskevicius, Algirdas;Grossman, Zehava;Horban, Anders;Kostrikis, Leondios G;Lepej, Snjezana J;Liitsola, Kirsi;Linka, Marek;Nielsen, Claus;Otelea, Dan;Paredes, Roger;Poljak, Mario;Puchhammer-Stöckl, Elizabeth;Schmit, Jean Claude;Sönnerborg, Anders;Staneková, Danica;Stanojevic, Maja;Stylianou, Dora C;Boucher, Charles A B;, ;Nikolopoulos, Georgios;Vasylyeva, Tetyana;Friedman, Samuel R;van de Vijver, David;Angarano, Gioacchino;Chaix, Marie-Laure;de Luca, Andrea;Korn, Klaus;Loveday, Clive;Soriano, Vincent;Yerly, Sabine;Zazzi, Mauricio;Vandamme, Anne-Mieke;Paraskevis, Dimitrios;
Journal Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Year 2016
DOI
S1567-1348(16)30223-4
URL
Keywords Keywords not found

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