controlled release of retinol in cationic co-polymeric nanoparticles for topical application

Clicks: 356
ID: 154998
2020
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Abstract
Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and temperature. Retinol can also generate toxicity at high concentrations. Microencapsulation is an alternative method to help overcome these issues. In this study, we develop a new encapsulation of retinol by solvent evaporation using a cationic polymer. We show that our particles have a narrow size distribution (350 nm), can encapsulate retinol with high efficiency, and protect it from oxidation for at least eight weeks. Finally, to demonstrate that the release of retinol from the particles can be controlled, we performed a kinetic study and showed that the particle releases the drug during 18 h.
Reference Key
goudon2020cosmeticscontrolled Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fabien Goudon;Yohann Clément;Lionel Ripoll
Journal journal of molecular catalysis a: chemical
Year 2020
DOI
10.3390/cosmetics7020029
URL
https://www.mdpi.com/2079-9284/7/2/29
Keywords
encapsulation drug release retinol

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