evaluation of primary haemostasis with platelet function analyser pfa-10
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Abstract
Background. Laboratory evaluation is indicated when a disorder of primary haemostasis is suspected by a personal or family history of easy bruising, nose bleeds, menorrhagia or postoperative bleeding, especially following dental extraction or tonsillectomy. The traditional procedures to diagnose defect in primary haemostasis are bleeding time, measurement of von Willebrand factor and platelet aggregometry. The most widely used screening test is bleeding time. Despite attempts at standardisation, the bleeding time remains poorly reproducible and is relatively insensitive to platelet function defects. Recently, a new test method, the platelet function analyser (PFA-100) has been introduced for the investigation of primary haemostasis. PFA-100 measures the ability of platelets activated in a high-shear environment to occlude an aperture in membrane treated with collagen and epinephrine and/or collagen and ADP. The time taken for flow across the membrane to stop (closure time) is recorded.
Conclusions. This article highlights the benefits and limitations of the clinical utility of the PFA-100. Because of its simplicity and excellent sensitivity the PFA-100 is useful mainly as a screening test for von Willebrand disease, hereditary and acquired platelet-dysfunctions including acetylsalicylic acidinduced abnormalities. Recently the PFA-100 has been shown to be of value in monitoring antiplatelet therapy and in monitoring desmopressin treatment in von Willebrand disease.
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| Authors | ;Uroš Mlakar;Irena Preložnik Zupan;Rika Strauch |
| Journal | planta medica |
| Year | 2004 |
| DOI |
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| Keywords | Keywords not found |
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