sirtuins – universal regulators of cell function
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2012
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Abstract
The silent information regulator (SIR) genes code for a highly conserved family of proteins from bacteria to mammals – sirtuins. Sirtuins are NAD+-dependent protein deacetylases with diverse physiological functions relating to cell survival, inflammation, energy metabolism, cancer. They are a part of complicated biological response system that influences many other regulator molecules and pathways. Sirtuins respond in an epigenetic manner to a variety of environmental factors, such as: dietary, lifestyle, toxins, etc. The data on the importance of vitamin B3 in supporting the sirtuin enzyme activity and a role of nicotinamide in inhibiting this activity are summarized. This mode of regulation may be exploited to manipulate the sirtuins activity in the context of various pathological conditions.
| Reference Key |
p.2012biopolymerssirtuins
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|---|---|
| Authors | ;Kaidashev I. P. |
| Journal | medicines |
| Year | 2012 |
| DOI |
10.7124/bc.000033
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| URL | |
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