human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology

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ID: 154652
2015
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Abstract
Most light-sensitive organisms on earth have acquired an internal system of circadian clocks allowing the anticipation of light or darkness. In humans, the circadian system governs nearly all aspects of physiology and behavior. Circadian phenotypes including chronotype vary dramatically among individuals and over individual lifespan. Recent studies have revealed that the characteristics of human skin fibroblast clocks correlate with donor chronotype. Given the complexity of circadian phenotype assessment in humans, the opportunity to study oscillator properties by using cultured primary cells has the potential to uncover molecular details difficult to assess directly in humans. Since altered properties of the circadian oscillator have been associated with many diseases including metabolic disorders and cancer, clock characteristics assessed in additional primary cell types using similar technologies might represent an important tool for exploring the connection between chronotype and disease, and for diagnostic purposes. Here we review implications of this approach for gathering insights into human circadian rhythms and their function in health and disease.
Reference Key
esaini2015frontiershuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Camille eSaini;Steven A Brown;Charna eDibner
Journal journal of photochemistry and photobiology a: chemistry
Year 2015
DOI
10.3389/fneur.2015.00095
URL
http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00095/full
Keywords
circadian clock diseases of the nervous system

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