effects of water deprivation on renal hydroelectrolytic excretion in chronically trypanosoma cruzi-infected rats

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ID: 154315
1995
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Abstract
The effect of an 8 hour-period of water deprivation on fluid and electrolyte renal excretion was investigated in male Wistar rats infected with the strain São Felipe (12SF) of Trypanosoma cruzi, in comparison with age and sex matched non-infected controls. The median percent reductions in the urinary flow (-40% v -63%) and excretion ofsodium (-57% v-79%) were smaller in chagasic than in control rats, respectively. So, chagasic rats excreted more than controls. On the other hand, the median percent decrement in the clearance of creatinine was higher in chagasic (-51%) than in controls (-39%). Thus, chagasic rats showed some disturbed renal hydroelectrolytic responses to water deprivation, expressed by smaller conservation, or higher excretion of water and sodium in association with smaller glomerularfiltration rate. This fact denoted an elevation in the fractional excretion of sodium and water.
O efeito de 8 horas do jejum hídrico sobre a excreção renal de sódio e água foi investigado em ratos Wistar machos infectados com a cepa São Felipe (12SF) do T. cruzi e comparados com ratos controles, de mesma idade e sexo. Durante a hidropenia, a mediana da redução no fluxo urinário (-40% v -63%) e a excreção urinária de sódio (-57% v -79%) foram menores nos chagásicos do que nos controles, respectivamente. Assim os ratos chagásicos excretaram mais do que os controles. Por outro lado, a mediana do decréscimo percentual na depuração de creaünina foi maior nos chagásicos (-51%) do que nos controles' (-39%,). Portanto, os ratos chagásicos mostraram alteração na resposta excretória hidroeletrolítica renal expressa por menor conservação de água e sódio em associação à menor taxa de filtração.
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rosa1995revistaeffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;T.T. Rosa;L.F. Junqueira Junior;F.J.C. Mangia;J.P.R. Veiga;F.V. Pádua
Journal mobile information systems
Year 1995
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000100002
Keywords
glomerular filtration rate water deprivation tropical medicine cruziarctic medicine

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