androgen action in the ovary

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ID: 154214
2018
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Abstract
Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell proliferation. It is likely only in mature antral follicles that androgens encourage apoptosis and consequent follicle atresia, and this may be an important mechanism to ensure mono-follicular ovulation in primates, including humans. Recent studies have provided new insight into the mechanism of androgen signaling in the ovary which involves both genomic and non-genomic effects that are complementary in effecting a cellular response. In polycystic ovary syndrome, a condition characterized by intra-ovarian androgen excess, aberrant development of both preantral and antral follicles is a salient feature. We present evidence that local action of androgens plays a part in such abnormalities. Finally, we review the role of androgens in follicle atresia and conclude that the effects are part of the normal physiology of follicle maturation.
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franks2018frontiersandrogen Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Stephen Franks;Kate Hardy
Journal aip advances
Year 2018
DOI
10.3389/fendo.2018.00452
URL
https://www.frontiersin.org/article/10.3389/fendo.2018.00452/full
Keywords
apoptosis polycystic ovary syndrome androgen receptor clinical endocrinology follicle atresiadiseases of the endocrine glands

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