drug susceptibility of plasmodium falciparum in the western amazon region, state of acre, brazil susceptibilidade a droga, do plasmodium falciparum, na amazônia ocidental, estado do acre, brasil

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ID: 154041
1991
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Abstract
Field studies in the western Amazon region (state of Acre, Brazil) indicate that the 4-aminoquinolines, as well as the combined regimen with sulfadoxine-pyrimethamine, can no longer be recomended for the treatment and prophylaxis of P. falciparum infections in this region. Quinine remains an effective drug when used correctly. However, compliance problems arise due to the often occurring side-effects during a ten day regimen. Prospects of overcoming these constraints by combining a short course of quinine with other drugs are limited, because of the lack of suitable partner compounds. For this reason quinine/clindamycin appears to be a more practical therapy of P. falciparum malaria. In vitro data from this study suggest that mefloquine is another effective alternative for the treatment of falciparum malaria in this Amazon region.
Estudos de campo na Amazonia ocidental (Estado do Acre, Brasil) indicam que as 4-aminoquinolinas, assim como a sua combinação com sulfadoxina-pirimetamina não podem mais ser recomendadas para o tratamento e profilaxia das infecções pelo P. falciparum nesta região. A quinina permanece como droga efetiva quando usada corretamente. Entretanto, problemas podem surgir devido aos efeitos colaterais durante sua aplicação por período de 10 dias. Possibilidades de ultrapassar estes problemas combinando curto espaço de administração da quinina com outras drogas estão no momento limitadas devido à falta de um composto associado adequado. Por esta razão, a combinação quinina/clindamicina parece ser a terapêutica mais adequada para a malária pelo P. falciparum. Nossos estudos in vitro sugerem que a mefloquina é outra alternativa efetiva para o tratamento da malária falciparum nesta região da Amazônia.
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neifer1991revistadrug Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;S. Neifer;P.G. Kremsner
Journal 2017 12th international conference for internet technology and secured transactions, icitst 2017
Year 1991
DOI
10.1590/S0036-46651991000300007
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651991000300007
Keywords
Drug resistance plasmodium falciparum tropical medicine acrearctic medicine

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