selected inflammatory and metabolic markers in psoriatic patients treated with goeckerman therapy

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ID: 153195
2015
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Abstract
Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n=32) and on a control group (n=24). Before GT, we found significantly elevated levels of proinflammatory CRP (p<0.001) and leptin (p<0.05) in psoriatic patients (compared to the controls). The therapy significantly decreased the levels of CRP and adiponectin. We found positive correlations between CRP and total duration of GT (p<0.05) and CRP and the time of UV exposure (p<0.01) and negative correlations between adiponectin and the total duration of GT (p<0.05) and adiponectin and the application of CCT ointment (p<0.001). From our results, we can conclude that GT causes partial reduction of both proinflammatory and anti-inflammatory markers. However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group.
Reference Key
kondelkova2015mediatorsselected Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Katerina Kondelkova;Lenka Borska;Ctirad Andrys;Jan Krejsek;Kvetoslava Hamakova;Simona Rendarova;Vit Rehacek;Jan Kremlacek;Zdenek Fiala
Journal polyhedron
Year 2015
DOI
10.1155/2015/979526
URL
http://dx.doi.org/10.1155/2015/979526
Keywords
pathology

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