the adenovirus genome contributes to the structural stability of the virion

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ID: 152944
2014
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Abstract
Adenovirus (Ad) vectors are currently the most commonly used platform for therapeutic gene delivery in human gene therapy clinical trials. Although these vectors are effective, many researchers seek to further improve the safety and efficacy of Ad-based vectors through detailed characterization of basic Ad biology relevant to its function as a vector system. Most Ad vectors are deleted of key, or all, viral protein coding sequences, which functions to not only prevent virus replication but also increase the cloning capacity of the vector for foreign DNA. However, radical modifications to the genome size significantly decreases virion stability, suggesting that the virus genome plays a role in maintaining the physical stability of the Ad virion. Indeed, a similar relationship between genome size and virion stability has been noted for many viruses. This review discusses the impact of the genome size on Ad virion stability and emphasizes the need to consider this aspect of virus biology in Ad-based vector design.
Reference Key
saha2014virusesthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bratati Saha;Carmen M. Wong;Robin J. Parks
Journal International journal of pharmaceutics
Year 2014
DOI
10.3390/v6093563
URL
http://www.mdpi.com/1999-4915/6/9/3563
Keywords
adenovirus viral vectors helper-dependent admicrobiology

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