epidemiology of human papillomavirus infections: new options for cervical cancer prevention epidemiología de las infecciones por el papilomavirus humano: nuevas opciones para la prevención del cáncer cervical

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ID: 152766
2003
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Abstract
In the last two decades, the cervical cancer puzzle has become a coherent description that includes the identification of human papillomavirus (HPV) as the sexually transmitted etiologic agent and the characterization of the major determinants of HPV acquisition. Triage studies have consistently shown that HPV testing is more sensitive that repeated cytology in identifying underlying high-grade lesions in women with atypical scamous cells of undetermined significance (ASCUS). Studies that reflect primary screening conditions have shown that the sensitivity of HPV tests is higher than standard cytology in detecting high-grade lesions whereas the specificity is similar only in women aged 30-35 and above. HPV vaccines have an intrinsic attraction as a preventive strategy in populations with limited resources. However, vaccines designed to widespread use are still in development and testing phases. Time is ripe for exploring in depth the clinical implications of current achievements and to devise novel strategies for the prevention of cervical cancer.
En las ultimas dos décadas, el enigma del cáncer cervical (CaCu) ha comenzado a ser dilucidado y actualmente se ha identificado a la infección por virus de papiloma humano (VPH) como su agente etiológico transmitido sexualmente, y se han caracterizado los principales determinantes de infección por VPH. Estudios epidemiológicos han mostrado consistentemente que las pruebas de determinación de ADN de VPH son más sensibles que la citología repetida para la identificación de lesiones de alto grado en mujeres con diagnóstico de células escamosas atípicas de significado indeterminado (ASCUS). Diversos estudios que evalúan el tamizaje primario en CaCu, han mostrado que la sensibilidad de las pruebas de VPH es más alta que la citología estándar para detectar lesiones de alto grado, donde la especificidad es similar sólo en mujeres con edades entre 30 y 35 años o mayores. Las vacunas de VPH tienen una atracción intrínseca como una estrategia preventiva en poblaciones con recursos limitados, sin embargo, el diseño de vacunas para uso generalizado están en fase de desarrollo y prueba. Actualmente, se deben de desarrollar investigaciones que exploren las implicaciones clínicas de la puesta en práctica de nuevas estrategias para la prevención de CaCu.
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bosch2003saludepidemiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;F. Xavier Bosch
Journal journal of anatomy
Year 2003
DOI
DOI not found
URL
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342003000900006
Keywords
human papillomavirus

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