roles of lncrnas in pancreatic beta cell identity and diabetes susceptibility

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ID: 152604
2014
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Abstract
Type 2 Diabetes usually ensues from the inability of pancreatic beta cells to compensate for incipient insulin resistance. The loss of beta cell mass, function and potentially beta cell identity contribute to this dysfunction to extents which are debated. In recent years, long non-coding RNAs (lncRNAs) have emerged as potentially providing a novel level of gene regulation implicating critical cellular processes such as pluripotency and differentiation. With over 1000 lncRNAs now identified in beta cells, there is growing evidence for their involvement in the above processes in these cells. While functional evidence on individual islet lncRNAs is still scarce, we discuss the how lncRNAs contribute to Type 2 Diabetes susceptibility, particularly at loci identified through Genome Wide Association Studies (GWAS) as affecting disease risk.
Reference Key
pullen2014frontiersroles Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Timothy James Pullen;Guy Allen Rutter
Journal chemical record (new york, ny)
Year 2014
DOI
10.3389/fgene.2014.00193
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00193/full
Keywords
type 2 diabetes lncrnas islets of langerhans

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