how do we manage high-grade t1 bladder cancer? conservative or aggressive therapy?
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2016
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Abstract
High-grade T1 bladder cancer has a poor prognosis due to a higher incidence of recurrence and progression than other nonmuscle
invasive bladder cancer; thus patients with high-grade T1 have to be carefully monitored and managed. If patients are diagnosed
with high-grade T1 at initial transurethral resection (TUR), a second TUR is strongly recommended regardless of whether muscle
layer is present in the specimen because of the possibility of understating due to incomplete resection. Since high-grade T1 disease
shows diverse clinical courses, individual approaches are recommended for treatment. In cases with low risk of progression, cystectomy
could represent overtreatment and deteriorate quality of life irreversibly, while, in those with high risk, bacillus Calmette–
Guérin (BCG) therapy may worsen survival by delaying definitive therapy. Therefore, a strategy for predicting prognosis based on
the risk of progression is needed for managing high-grade T1 disease. Molecular risk classifiers predicting the risk of progression
and response to BCG may help identify the optimal management of high-grade T1 disease for each individual.
| Reference Key |
yun2016investigativehow
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| Authors | ;Seok Joong Yun;Seon-Kyu Kim;Wun-Jae Kim |
| Journal | ciência rural |
| Year | 2016 |
| DOI |
10.4111/icu.2016.57.S1.S44
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