analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention

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ID: 152573
2011
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Abstract
Serum from men undergoing a low-fat, high-fiber diet and exercise intervention has previously been shown to decrease growth and increase apoptosis in serum-stimulated, androgen-dependent LNCaP cells associated with a reduction in serum IGF-I. Here we sought to determine the underlying mechanisms for these anticancer effects. Again, the intervention slowed growth and increased apoptosis in LNCaP cells; responses that were eliminated when IGF-I was added back to the post-intervention samples. The p53 protein content was increased and NFκB activation reduced in the post serum-stimulated LNCaP cells. Similar results were observed when the IGF-I receptor was blocked in the pre-intervention serum. In androgen-independent PC-3 cells, growth was reduced while none of the other factors were changed by the intervention. We conclude that diet and exercise intervention might help prevent clinical PCa as well as aid in the treatment of PCa during the early stages of development.
Reference Key
soliman2011evidence-basedanalyzing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sherry Soliman;William J. Aronson;R. James Barnard
Journal ACS applied materials & interfaces
Year 2011
DOI
10.1093/ecam/nep031
URL
http://dx.doi.org/10.1093/ecam/nep031
Keywords
Other systems of medicine

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