unveiling protein kinase a targets in cryptococcus neoformans capsule formation

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ID: 152380
2016
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Abstract
The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase A (PKA) activation and repression in the opportunistic human fungal pathogen Cryptococcus neoformans. They observed an association between microbial PKA signaling and ubiquitin-proteasome regulation of protein homeostasis. Additionally, they correlated these processes with expression of polysaccharide capsule on the fungal cell surface, the main virulence-associated phenotype in this organism. Not only are their findings important for microbial pathogenesis, but they also support similar associations between human PKA signaling and ubiquitinated protein accumulation in neurodegenerative diseases.
Reference Key
alspaugh2016mbiounveiling Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;J. Andrew Alspaugh
Journal synlett
Year 2016
DOI
10.1128/mBio.00021-16
URL
http://mbio.asm.org/cgi/content/full/7/1/e00021-16
Keywords
Microbiology

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