a potential sensing mechanism for dna nucleobases by optical properties of go and mos 2 nanopores

Clicks: 318
ID: 152246
2019
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Ranked #21 of 107 articles by views in historia de la educación

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Abstract
Abstract We propose a new DNA sensing mechanism based on optical properties of graphene oxide (GO) and molybdenum disulphide (MoS 2) nanopores. In this method, GO and MoS 2 is utilized as quantum dot (QD) nanopore and DNA molecule translocate through the nanopore. A recently-developed hybrid quantum/classical method (HQCM) is employed which uses time-dependent density functional theory and quasi-static finite difference time domain approach. Due to good biocompatibility, stability and excitation wavelength dependent emission behavior of GO and MoS 2 we use them as nanopore materials. The absorption and emission peaks wavelengths of GO and MoS 2 nanopores are investigated in the presence of DNA nucleobases. The maximum sensitivity of the proposed method to DNA is achieved for the 2-nm GO nanopore. Results show that insertion of DNA nucleobases in the nanopore shifts the wavelength of the emitted light from GO or MoS 2 nanopore up to 130 nm. The maximum value of the relative shift between two different nucleobases is achieved by the shift between cytosine (C) and thymine (T) nucleobases, ~111 nm for 2-nm GO nanopore. Results show that the proposed mechanism has a superior capability to be used in future DNA sequencers.
Reference Key
faramarzi2019scientifica Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vahid Faramarzi;Vahid Ahmadi;Bashir Fotouhi;Mostafa Abasifard
Journal historia de la educación
Year 2019
DOI
10.1038/s41598-019-41165-6
URL
http://link.springer.com/article/10.1038/s41598-019-41165-6
Keywords
medicinescience

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