urothelial cancer with occult bone marrow metastases and isolated thrombocytopenia

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ID: 152229
2015
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Abstract
Bladder cancer rarely presents clinically with a myelophthisic picture from diffuse bone marrow infiltration especially in the absence of detectable skeletal metastases. A 75-year old man presented with newly diagnosed urothelial cell carcinoma of the bladder. Pathology from transurethral resection of bladder tumor demonstrated muscle-invasive disease. Pre-therapy imaging including CT abdomen/pelvis, CXR and bone scan demonstrated liver lesions concerning for metastatic disease but no skeletal metastases. Labs were notable for isolated thrombocytopenia, hypercalcemia and acute kidney injury prompting hospitalization. Hematologic work-up including bone marrow aspiration and biopsy revealed diffuse infiltration of the bone marrow by urothelial cancer. The case illustrates the importance of fully investigating otherwise unexplained clinical findings in patients with clinically localized urothelial cancer prior to curative intent surgery.
Reference Key
alva2015urologyurothelial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ajjai Alva;Elizabeth Davis;Arul M. Chinnaiyan;Saravana Dhanasekaran;Rohit Mehra
Journal advances in human-computer interaction
Year 2015
DOI
10.1016/j.eucr.2015.01.007
URL
http://www.sciencedirect.com/science/article/pii/S221444201500008X
Keywords
urology bone marrow metastases

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