caracterÍsticas fÍsico-quÍmicas e citolÓgicas do lÍquido sinovial de pÔneis com modelo de sinovite induzida physical, biochemical and cytological characteristics of synovial fluid with induced synovitis model in ponies

Clicks: 148
ID: 151842
2009
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Abstract
<div>O objetivo deste estudo foi descrever as principais alterações do líquido sinovial de seis pôneis com sinovite induzida através da administração intra-articular de 0,5 mL de adjuvante completo de Freund. As características físico-químicas e citológicas foram avaliadas antes da indução da sinovite (T0), cinco dias pós-indução (T1) e, a partir daí, às 12 (T2), 24 (T3), 48 (T4), 72 (T5), 96 (T6) e 120 horas (T7). A articulação contralateral sadia serviu como controle. A proteína, a viscosidade e a qualidade da precipitação da mucina não diferiram (P>0,05) entre as articulações em T0. Em T1, o líquido sinovial das articulações com sinovite apresentou aumento da concentração de proteína (6,5 g/dl), baixa viscosidade e baixa qualidade do precipitado da mucina, resultados que permaneceram estáveis até T7. Nas articulações sadias não foi observada diferença na viscosidade e qualidade da mucina até o final do experimento, mas, devido às artrocenteses, a proteína aumentou (p<0,05) em T6 e T7. Nas articulações induzidas houve aumento acentuado (p<0,05) de células nucleadas (>700 células/mm3) em T1, com decréscimo em T3, mas permanecendo em níveis considerados inflamatórios durante todo tempo de observação. A contagem diferencial revelou predominância de neutrófilos e presença de células mesoteliais reativas. A infiltração intra-articular com 0,5 mL de adjuvante completo de Freund produz uma sinovite neutrofílica de intensidade moderada a grave, semelhante à sinovite de ocorrência natural, reforçando a eficácia desse modelo para o estudo da patofisiologia e tratamento de doenças articulares.</div><div><br /></div><div>PALAVRAS-CHAVES: Articulação, equino, líquido sinovial, sinovite.</div><div><br /></div> The aim of this study was to describe the changes of the synovial fluid caused by experimental synovitis induced by an intra-articular injection of 0.5 mL of Freund’s complete adjuvant in six adult ponies. The physical-chemical and cytological parameters were evaluated before the synovitis induction (T0), 5 days after induction (T1) and, after that, at 12 (T2), 24 (T3), 48 (T4), 72 (T5), 96 (T6) and 120 hours (T7). The contra lateral joint served as healthy control. The protein, viscosity and mucin precipitation quality did not differ (P>0.05) among the joints in T0. At T1, the synovial fluid of the joints with synovitis showed an increased protein concentration (6.5 g/dl), low viscosity and low mucin precipitate quality, which remained stable until T7. Viscosity and mucin precipitate quality did not change in the synovial fluid of healthy joints until the end of the experiment. Due to repeated arthrocentesis, protein increased (p <0.05) at T6 and T7. Joints with synovitis had an increased total nucleated cell count (>700 cells/mm3, p <0.05) at T1, that decreased at T3, remaining on an inflammatory level during the observation period. The differential cell count showed neutrophil predominance and presence of reactive mesothelial cells. The intra-articular injection of 0.5 mL of Freund’s complete adjuvant produced a neutrophilic synovitis of moderate to severe intensity, similar to the natural synovitis, reinforcing the effectiveness of this model in the study of the pathophysiology and treatment of joint diseases.<div><br /></div><div>KEY WORDS: Equine orthopedics, synovitis, synovial fluid.</div>
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pozzobon2009cinciacaractersticas Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ricardo Pozzobon;Karin Erica Brass;Rafael Almeida Fighera;Flávio Dessessards De La Corte
Journal proceedings of the winter simulation conference winter simulation conference
Year 2009
DOI
DOI not found
URL
http://www.revistas.ufg.br/index.php/vet/article/view/4491
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