cembranoids from a chinese collection of the soft coral lobophytum crassum
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ID: 151759
2016
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Abstract
Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM.
| Reference Key |
zhao2016marinecembranoids
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|---|---|
| Authors | ;Min Zhao;Shimiao Cheng;Weiping Yuan;Yiyuan Xi;Xiubao Li;Jianyong Dong;Kexin Huang;Kirk R. Gustafson;Pengcheng Yan |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2016 |
| DOI |
10.3390/md14060111
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| URL | |
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