assessing a new method for measuring fetal exposure to mercury: newborn bloodspots
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2016
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Abstract
Background: Measuring mercury in newborn bloodspots to determine fetal exposures is a novel methodology with many advantages. Questions remain, however, about its reliability as an estimate of newborn exposure to mercury. Methods: We studied mercury concentrations in paired bloodspots and cord blood from a convenience sample of 48 Minnesota women and infants. Results: The limit of detection for bloodspots was higher than for cord blood (0.7 and 0.3 μg/L in bloodspots and cord blood, respectively) with the result that mercury was detected in only 38% of newborn bloodspots compared to 62% of cord blood samples. The geometric mean mercury concentration in cord blood was 0.6 μg/L. Mercury concentrations were almost uniformly lower in bloodspots than in cord blood (mean ratio (±SD) = 0.85 ± 0.4), their mean value was significantly less than that for the cord blood (p = 0.02), and the two methods were highly correlated (r = 0.82). Conclusion: These preliminary findings indicate that newborn bloodspot mercury measurements have utility; however, until bloodspot analyses are more sensitive, they are likely to underestimate in utero exposure.
| Reference Key |
nelson2016internationalassessing
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| Authors | ;Jessica W. Nelson;Betsy L. Edhlund;Jean Johnson;Christina E. Rosebush;Zachary S. Holmquist;Shanna H. Swan;Ruby H. N. Nguyen |
| Journal | archives of biochemistry and biophysics |
| Year | 2016 |
| DOI |
10.3390/ijerph13070692
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