in vivo production of monoclonal antibodies by gene transfer via electroporation protects against lethal influenza and ebola infections

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ID: 151670
2017
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Abstract
Monoclonal antibodies (mAbs) have wide clinical utility, but global access is limited by high costs and impracticalities associated with repeated passive administration. Here, we describe an optimized electroporation-based DNA gene transfer platform technology that can be utilized for production of functional mAbs in vivo, with the potential to reduce costs and administration burdens. We demonstrate that multiple mAbs can be simultaneously expressed at protective concentrations for a protracted period of time using DNA doses and electroporation conditions that are feasible clinically. The expressed mAbs could also protect mice against lethal influenza or Ebola virus challenges. Our findings suggest that this DNA gene transfer platform technology could be a game-changing advance that expands access to effective mAb therapeutics globally.
Reference Key
andrews2017molecularin vivo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Chasity D. Andrews;Yang Luo;Ming Sun;Jian Yu;Arthur J. Goff;Pamela J. Glass;Neal N. Padte;Yaoxing Huang;David D. Ho
Journal international journal of zoology
Year 2017
DOI
10.1016/j.omtm.2017.09.003
URL
http://www.sciencedirect.com/science/article/pii/S232905011730102X
Keywords
plasmid infectious disease influenza electroporation ebolageneticscytology

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