boehmeria nivea attenuates the development of dextran sulfate sodium-induced experimental colitis
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ID: 151663
2014
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Abstract
We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest that B. nivea extract is effective in preventing colitis.
| Reference Key |
shin2014mediatorsboehmeria
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|---|---|
| Authors | ;Eun Ju Shin;Mi Jeong Sung;Hye Jeong Yang;Myung Sunny Kim;Jin-Taek Hwang |
| Journal | polyhedron |
| Year | 2014 |
| DOI |
10.1155/2014/231942
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| URL | |
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