denatured lysozyme-coated carbon nanotubes: a versatile biohybrid material

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ID: 151209
2019
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Abstract
Abstract Carbon nanotubes (CNTs) are among the most versatile nanomaterials, but their exploitation is hindered by limited dispersibility, especially in aqueous solvents. Here, we show that AP-LYS, a highly cationic soluble derivative of denatured hen egg lysozyme, is a very effective tool for the unbundling and solubilisation of CNTs. AP-LYS proved to mediate the complete and stable dispersion of CNTs at protein: CNT ratios ≥1: 3 (w:w) in very mild conditions (10–20 minutes sonication in ammonium acetate buffer, pH 5.0). Electrophoretic mobility and ζ-potential measurements confirmed that dispersed CNTs were coated by the protein, whereas molecular docking was used to study the interactions between AP-LYS and CNTs. AP-LYS-coated CNTs proved to be a very effective microbial cell-flocculating agent with an efficiency similar to that of chitosan, one of the best available flocculating agents, thus suggesting that this hybrid could find industrial applications in the treatment of wastewaters contaminated by microbial cells, or to remove microbial cells after fermentation processes. Moreover, we exploited the low stability of AP-LYS-coated CNT dispersions in eukaryotic cell culture media to prepare scaffolds with an extracellular matrix-like rough surface for the cultivation of eukaryotic cells.
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siepi2019scientificdenatured Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marialuisa Siepi;Giuliana Donadio;Principia Dardano;Luca De Stefano;Daria Maria Monti;Eugenio Notomista
Journal historia de la educación
Year 2019
DOI
10.1038/s41598-019-52701-9
URL
http://link.springer.com/article/10.1038/s41598-019-52701-9
Keywords
medicinescience

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