fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas

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ID: 151206
2017
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Abstract
Abstract Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isolated from clinical specimens of NFPAs with or without bone destruction. Proteomic analysis revealed a group of molecules associated with cytoskeleton organization, including caldesmon, were differentially expressed between fibroblasts isolated from bone destruction NFPAs (BD-NFPAs) and fibroblasts isolated from non-bone destruction NFPAs (NBD-NFPAs). The secreted proteins analysis found that osteopontin was significantly upregulated in BD-NFPAs fibroblasts. Furthermore, immunohistochemical staining of the NFPAs clinical samples showed that the expression of caldesmon in stromal cells and the expression of osteopontin in both tumor cells and stroma were significantly increased in BD-NFPAs. Taken together, our results indicate a possible way that osteopontin secreted from both NFPA cells and surrounding fibroblasts modify caldesmon expression and polymerization in fibroblasts, which may contribute to bone destruction in NFPA patients.
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zhang2017scientificfibroblasts Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Li-yang Zhang;Xiao-lu Ge;Zheng Li;Yong-jian Tang;Yuan-yuan Xiong;Xue-jun Li;Jin-fang Liu;Si-yi Wanggou;Chun-tao Li;Kui Yang;Xin Chen;Zhong-Liang Hu;Yun-sheng Liu;Zhi-Xiong Liu
Journal historia de la educación
Year 2017
DOI
10.1038/s41598-017-17679-2
URL
http://link.springer.com/article/10.1038/s41598-017-17679-2
Keywords
medicinescience

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