hypocretin (orexin) regulation of sleep-to-wake transitions
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2014
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Abstract
The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here I discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. I conclude that Hcrt neurons integrate metabolic, circadian and limbic inputs and convey this information to a network of neuromodulators, each of which has a different role on the dynamic of sleep-to-wake transitions. This model may prove useful to predict the effects of orexin receptor antagonists in sleep disorders and other conditions.
| Reference Key |
lecea2014frontiershypocretin
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| Authors | ;Luis eDe Lecea;Ramon eHuerta |
| Journal | chemical research in chinese universities |
| Year | 2014 |
| DOI |
10.3389/fphar.2014.00016
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