two new monoterpene glycosides from qing shan lu shui tea with inhibitory effects on leukocyte-type 12-lipoxygenase activity
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ID: 150880
2013
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Abstract
We evaluated the inhibitory effect of 12 Chinese teas on leukocyte-type 12-lipoxygenase (LOX) activity. Tea catechins such as epigallocatechin gallate have been known to exhibit leukocyte-type 12-LOX inhibition. Qing Shan Lu Shui, which contains lower catechin levels than the other tested teas, suppressed leukocyte-type 12-LOX activity. To characterize the bioactive components of Qing Shan Lu Shui, leukocyte-type 12-LOX inhibitory activity–guided fractionation of the aqueous ethanol extract of the tea was performed, resulting in the isolation of two new monoterpene glycosides: liguroside A (1) and B (2). The structures of compounds 1 and 2 were characterized as (2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octadienyl-O-(α-L-rhamnopyranosyl)-(1″→3′)-(4′″-O-trans-p-coumaroyl)-β-D-glucopyranoside and (2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octa-dienyl- O-(α-L-rhamnopyranosyl)-(1″→3′)-(4′″-O-cis-p-coumaroyl)-β-D-glucopyranoside, respectively, based on spectral and chemical evidence. Ligurosides A (1) and B (2) showed inhibitory effects on leukocyte-type 12-LOX activity, with IC50 values of 1.7 and 0.7 μM, respectively.
| Reference Key |
fang2013moleculestwo
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|---|---|
| Authors | ;Ding Zhi Fang;Hideaki Tsuji;Yuki Kawakami;Mai Kinoshita;Peng Li;Hitomi Mori;Akemi Otsuki;Hideyuki Ito;Yoshitaka Takahashi |
| Journal | Journal of ethnopharmacology |
| Year | 2013 |
| DOI |
10.3390/molecules18044257
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| URL | |
| Keywords | Keywords not found |
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