sub-chronic exposure to eomabrs leachate induces germinal epithelial cell lesions, sperm abnormalities and oxidative damage in rats

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ID: 149768
2015
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Abstract
Objectives: To explore the possible link between reproductive abnormalities among men and exposure of toxic chemicals in the environment. Methods: The study investigated the sperm functions and the antioxidant defence system of rats exposed to leachate obtained from Elewi Odo municipal battery recycling site (EOMABRSL) via oral route. Results: EOMABRSL had significant effects on both absolute and relative testicular weight. Formation of sperm abnormalities was observed following EOMABRSL exposure. Antioxidant enzymes including superoxide dismutase and catalase were significantly altered in the testes resulting into increased lipid peroxidation. Reduced glutathione (GSH) levels were found to be significantly (P < 0.05) depleted relative to the control group. Considerable necrosis of leydig cells and loss of germ cells in the seminiferous tubules with the clumping of interstitial space were seen in EOMABRSL-treated rats. The mechanism of toxicity is linked to individual, synergistic, antagonistic, competitive or collective interaction of the metals with normal testicular biochemical processes. Conclusion: The study concluded that possible mechanisms by which EOMABRSL at the investigated doses elicits spermatotoxicity could be linked to the testicular oxidative stress and damage to germinal epithelial cells by mixed-metal exposure. However, this may suggest possible reproductive health hazards in subjects with environmental or industrial exposure.
Reference Key
akintunde2015asiansub-chronic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;J.K. Akintunde;G. Oboh;A.A. Akindahunsi
Journal Radiology
Year 2015
DOI
10.1016/j.apjr.2015.07.006
URL
http://www.sciencedirect.com/science/article/pii/S230505001500024X
Keywords
oxidative damage male ratsmedicine

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