tetrodotoxin (ttx) as a therapeutic agent for pain
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ID: 149484
2012
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Abstract
Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs). VGSCs play a critical role in neuronal function under both physiological and pathological conditions. TTX has been extensively used to functionally characterize VGSCs, which can be classified as TTX-sensitive or TTX-resistant channels according to their sensitivity to this toxin. Alterations in the expression and/or function of some specific TTX-sensitive VGSCs have been implicated in a number of chronic pain conditions. The administration of TTX at doses below those that interfere with the generation and conduction of action potentials in normal (non-injured) nerves has been used in humans and experimental animals under different pain conditions. These data indicate a role for TTX as a potential therapeutic agent for pain. This review focuses on the preclinical and clinical evidence supporting a potential analgesic role for TTX. In addition, the contribution of specific TTX-sensitive VGSCs to pain is reviewed.
| Reference Key |
cendn2012marinetetrodotoxin
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|---|---|
| Authors | ;Cruz Miguel Cendán;Cristina Sánchez-Fernández;Rafael González-Cano;Miguel Ángel Tejada;Enrique José Cobos;Francisco Rafael Nieto |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2012 |
| DOI |
10.3390/md10020281
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| URL | |
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