prdm proteins: molecular mechanisms in signal transduction and transcriptional regulation

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ID: 149114
2013
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Abstract
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats. Experimental evidence has shown that the PRDM proteins play an important role in gene expression regulation, modifying the chromatin structure either directly, through the intrinsic methyltransferase activity, or indirectly through the recruitment of chromatin remodeling complexes. PRDM proteins have a dual action: they mediate the effect induced by different cell signals like steroid hormones and control the expression of growth factors. PRDM proteins therefore have a pivotal role in the transduction of signals that control cell proliferation and differentiation and consequently neoplastic transformation. In this review, we describe pathways in which PRDM proteins are involved and the molecular mechanism of their transcriptional regulation.
Reference Key
moncharmont2013biologyprdm Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bruno Moncharmont;Ciro Abbondanza;Caterina De Rosa;Erika Di Zazzo
Journal Journal of microencapsulation
Year 2013
DOI
10.3390/biology2010107
URL
http://www.mdpi.com/2079-7737/2/1/107
Keywords
signal transduction transcriptional regulationbiology (general)

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