the mechanisms underlying chronic inflammation in rheumatoid arthritis from the perspective of the epigenetic landscape

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ID: 149107
2016
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Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and environmental factors have been reported to be involved in the etiology of RA but are insufficient to explain it. In recent years, accumulating results have shown the potential role of epigenetic mechanisms, including histone modifications, DNA methylation, and microRNAs, in the development of RA. Epigenetic mechanisms regulate chromatin state and gene transcription without any change in DNA sequence, resulting in the alteration of phenotypes in several cell types, especially RASFs. Epigenetic changes possibly provide RASFs with an activated phenotype. In this paper, we review the roles of epigenetic mechanisms relevant for the progression of RA.
Reference Key
araki2016journalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yasuto Araki;Toshihide Mimura
Journal journal of photochemistry and photobiology b, biology
Year 2016
DOI
10.1155/2016/6290682
URL
http://dx.doi.org/10.1155/2016/6290682
Keywords
immunologic diseases allergy

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