an animal model for febrile seizure induction using hot water bath
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2013
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Abstract
Background and Aim: Animal models offer an
opportunity to induce febrile seizures in laboratories to assess the effects of
neonatal fever and seizure on the central nervous system CNS). The present
study aimed at introducing a method for febrile seizure induction in newborn
rats. Materials and Methods: In order to induce hyperthermia, a number of
22-day-old male rats were placed in a 45 °C water tank for 4 minutes. Then, based on the
four-stage scale, the animals which showed seizure signs were divided into 4
groups. After
this stage, ten pups from the groups, which
had hyperthermia and seizure, were selected for further investigations. The
animals which presented no seizure behaviors were taken as hyperthermia without
seizure (n=10) group. To control the effects of environmental stress a
sham-control group consisting 10 rats were also included in the study. Results: A significant elevation in the animals' body temperature in all
groups was observed in comparison to the sham controls (P<0.05).No mortality
was seen in the sham-control, hyperthermia without seizure, and 1st
seizure stage groups., But 10% in each of the 2nd and 3rd
seizure stage groups and 30% in the 4th group were died. Duration of
seizure in the groups II, III, and IV was 89.46, 121.57, and 198.49 seconds,
respectively. Conclusion: Hot water bath model seems to be an efficient method to induce
febrile seizure in lab animals, and the interested researchers can consider it.
| Reference Key |
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| Authors | ;Mohamad Javad Saeedi Borujeni;Ghasem Sazegar;Seyyed Mojtaba Mousavi;Javad Hami;Hossein Haghir;Fatemeh Alipour |
| Journal | bmc evolutionary biology |
| Year | 2013 |
| DOI |
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