clinico-therapeutic studies on canine transmissible venereal tumour
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ID: 148617
2001
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Abstract
Ten-bitches and 8-male dogs afflicted with transmissible venereal tumour (TVT) randomly divided into 3 groups viz. Group-I, Group-II and Group-III comprising 6 dogs each, were subjected to three different protocols. Group-I was treated surgically. A complete regression of the tumour mass was observed in 4 (66.67%) dogs, while 2 (33.34%) had incomplete regression at the end of first 5 weeks. A 16.67% recurrence rate was also observed at the end of 6 months study period. In Group-III, chemotherapy with intravenous injection of vincristine sulphate @ 0.025 mg/kg b.wt. affected 80.33% (n=5) complete regression whereas incomplete regression was recorded in only one (16.67%) subject at the end of 5th week. Vomiting and inappetance as side-effects were also noticed. Group-III was subjected to a combination of surgery and chemotherapy where vincristine sulphate was used after surgical debulking of tumour mass. A 100% regression even after 2-3 injections with no recurrence was achieved till 6 months post-treatment. There was a significant increase (P≤0.01) in erythrocyte sedimentation rate and total leukocyte count (TLC) in TVT -afflicted dogs which returned to normal after 2-5 weeks of treatment. Vincristine sulphate had a significant decreasing effect on TLC in both Group-II and Group-III, which was transient.
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azim2001pakistanclinico-therapeutic
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| Authors | ;M. Athar, A. Suhail, G. uhammad, A. Shakoor and F. Azim |
| Journal | ecti damt-ncon 2019 - 4th international conference on digital arts, media and technology and 2nd ecti northern section conference on electrical, electronics, computer and telecommunications engineering |
| Year | 2001 |
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