the effects of needling fenglong (st40) and neiguan (pc6) on il-17 of apoe-gene-knockout mice’s liver

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ID: 148561
2014
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Abstract
The aim of the present paper was to observe the effects of needling ST40 and PC6 on IL-17 of ApoE−/− mice with fatty liver. Forty male ApoE−/− mice were randomized into Needling-Acupoint Group, Simvastatin Intragastric Administration Group, Needling Nonacupoint Group, and Model Group. Each was fed with high fat diet for 8 weeks since 16 weeks of age; after 8 weeks of intervention, mice were sacrificed and tested for various examinations. Result showed that the body weight, TC, and serum IL-17 in Needling-Acupoint Group decreased. Compared with Model Group, the immunohistochemical expressions of IL-17 in liver tissue were significantly decreased among the other three groups. In conclusion, acupuncture was able to lower the expression of IL-17 level both in serum and liver tissue in ApoE−/− mice, which is helpful to reduce the inflammation and defers the progress from fatty liver to cirrhosis.
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lee2014evidence-basedthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fu Yun Lee;Ze Jun Huo;Li Zhang;Jia Guo;Huan Chen;Tong Liu;Bo Peng;Pei Xin Hong;Yuan Yuan Peng;Yi Fan Fan;Yu Pei Chen
Journal ACS applied materials & interfaces
Year 2014
DOI
10.1155/2014/691863
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