evidence of oropharyngeal dysfunction in feeding in the rat rotenone model of parkinson’s disease
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ID: 148505
2018
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Abstract
Swallowing disorders in Parkinson’s disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson’s disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing. Dose-dependent effects were evident. These preliminary results indicate that future research in toxicological models of Parkinson’s disease should incorporate the study of oropharyngeal dysfunction. A better understanding of nongenetic models of Parkinson’s disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson’s disease.
| Reference Key |
gould2018parkinson'sevidence
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| Authors | ;François D. H. Gould;Andrew Gross;Rebecca Z. German;Jason R. Richardson |
| Journal | heat and mass transfer/waerme- und stoffuebertragung |
| Year | 2018 |
| DOI |
10.1155/2018/6537072
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| URL | |
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