tuberatolide b suppresses cancer progression by promoting ros-mediated inhibition of stat3 signaling

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ID: 148463
2017
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Abstract
Tuberatolide B (TTB, C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of TTB remain unknown. In this study, we demonstrate that TTB inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. To examine the mechanism by which TTB suppresses cell growth, we determined the effect of TTB on apoptosis, ROS generation, DNA damage, and signal transduction. TTB induced ROS production in MDA-MB-231, A549, and HCT116 cells. Moreover, TTB enhanced DNA damage by inducing γH2AX foci formation and the phosphorylation of DNA damage-related proteins such as Chk2 and H2AX. Furthermore, TTB selectively inhibited STAT3 activation, which resulted in a reduction in cyclin D1, MMP-9, survivin, VEGF, and IL-6. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, TTB suppresses cancer progression by promoting ROS-mediated inhibition of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.
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choi2017marinetuberatolide Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Youn Kyung Choi;Junseong Kim;Kang Min Lee;Yu-Jeong Choi;Bo-Ram Ye;Min-Sun Kim;Seong-Gyu Ko;Seung-Hong Lee;Do-Hyung Kang;Soo-Jin Heo
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2017
DOI
10.3390/md15030055
URL
http://www.mdpi.com/1660-3397/15/3/55
Keywords
Cancer stat3 ros

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