Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors.

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ID: 14845
2019
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Abstract
A series of new triazole fused imidazo[2,1-b]thiazole hybrids (9a-u) were designed, synthesized and evaluated as antimicrobial agents. Compounds 9c, 9d, 9e, 9j and 9l showed promising broad spectrum antimicrobial activity. Further, compound 9c exhibited significant anti-biofilm activity with single and mixed biofilm disruption demonstrated by Field Emission Scanning Electron Microscope (FE-SEM). Furthermore, molecular docking studies revealed that they interact with the virulence factor, Staphylococcus aureus dehydrosqualene synthase (CrtM) (PDB ID: 2ZCS). Overall, the findings suggest compound 9c as potential lead for further development of novel antibacterial and anti-biofilm agents.
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shareef2019synthesisbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shareef, Mohd Adil;Sirisha, Kanugala;Sayeed, Ibrahim Bin;Khan, Irfan;Ganapathi, Thipparapu;Akbar, Syed;Ganesh Kumar, C;Kamal, Ahmed;Nagendra Babu, Bathini;
Journal Bioorganic & medicinal chemistry letters
Year 2019
DOI
S0960-894X(19)30545-1
URL
Keywords Keywords not found

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