Anti-cancer potential of novel glycosylated 1,4-substituted triazolylchalcone derivatives.

Clicks: 211
ID: 14831
2019
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Ranked #129 of 246 articles by views in Bioorganic & medicinal chemistry letters

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Abstract
A series of glycosylated 1,4-substituted triazolyl chalcone derivatives (8a-f and 14a-r) were synthesized in high yield using 1,3-cycloaddition (Click chemistry) of d-glucosyl azides with a variety of propargylated chalcone derivatives followed by de-O-acetylation. The synthesized compounds were evaluated for their cytotoxic potential against the human breast carcinoma cell lines and non-cancerous cells. The MTT assay identified three promising cytotoxic compounds (14c, 14i and 14l) and further biochemical and microscopic studies were carried out with the best compound 14i among the active compounds.
Reference Key
manna2019anticancerbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Manna, Tapasi;Pal, Kunal;Jana, Kuladip;Misra, Anup Kumar;
Journal Bioorganic & medicinal chemistry letters
Year 2019
DOI
S0960-894X(19)30547-5
URL
Keywords Keywords not found

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