dual therapeutic functions of f-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs
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ID: 147943
2016
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Abstract
Burn injuries are a leading cause of morbidity including prolonged hospitalization, disfigurement, and disability. Currently there is no Food and Drug Administration-approved burn therapeutics. A clinical distinction of burn injuries from other acute wounds is the event of the so-called secondary burn wound progression within the first week of the injury, in which a burn expands horizontally and vertically from its initial boundary to a larger area. Therefore, an effective therapeutics for burns should show dual abilities to prevent the burn wound progression and thereafter promote burn wound healing. Herein we report that topically applied F-5 fragment of heat shock protein-90α is a dual functional agent to promote burn wound healing in pigs. First, F-5 prevents burn wound progression by protecting the surrounding cells from undergoing heat-induced caspase 3 activation and apoptosis with increased Akt activation. Accordingly, F-5–treated burn and excision wounds show a marked decline in inflammation. Thereafter, F-5 accelerates burn wound healing by stimulating the keratinocyte migration-led reepithelialization, leading to wound closure. This study addresses a topical agent that is capable of preventing burn wound progression and accelerating burn wound healing.
| Reference Key |
bhatia2016moleculardual
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|---|---|
| Authors | ;Ayesha Bhatia;Kathryn O'Brien;Mei Chen;Alex Wong;Warren Garner;David T. Woodley;Wei Li |
| Journal | international journal of zoology |
| Year | 2016 |
| DOI |
10.1038/mtm.2016.41
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| URL | |
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