c/ebp-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of b cells
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ID: 147695
2017
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Abstract
The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of any C/EBP, and enhanced by endogenous C/EBPα and β activation. High transgene expression of C/EBPβ or C/EBPε, but not of C/EBPα or C/EBPδ, also induced the formation of granulocytes. Granulocytes and macrophages emerged in a mutually exclusive manner. C/EBPβ-expressing B cells produced granulocyte-macrophage progenitor (GMP)-like progenitors when subjected to selective pressure to eliminate lymphoid cells. The GMP-like progenitors remained self-renewing and cytokine-independent, and continuously produced macrophages and granulocytes. In addition to their suitability to study myelomonocytic lineage bifurcation, lineage-switched GMP-like progenitors could reflect the features of the lympho-myeloid lineage switch observed in leukemic progression.
| Reference Key |
cirovic2017stemc/ebp-induced
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|---|---|
| Authors | ;Branko Cirovic;Jörg Schönheit;Elisabeth Kowenz-Leutz;Jelena Ivanovska;Christine Klement;Nina Pronina;Valérie Bégay;Achim Leutz |
| Journal | nature reviews gastroenterology & hepatology |
| Year | 2017 |
| DOI |
10.1016/j.stemcr.2016.12.015
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