cellular and molecular basis of neurodegeneration in parkinson disease

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ID: 147694
2018
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Abstract
It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in 1817. The disease is the second most common neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although the pathogenesis of PD is still unknown, the research findings from scientists are conducive to understand the pathological mechanisms. It is well accepted that both genetic and environmental factors contribute to the onset of PD. In this review, we summarize the mutations of main seven genes (α-synuclein, LRRK2, PINK1, Parkin, DJ-1, VPS35 and GBA1) linked to PD, discuss the potential mechanisms for the loss of dopaminergic neurons (dopamine metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, impaired autophagy, and deregulation of immunity) in PD, and expect the development direction for treatment of PD.
Reference Key
zeng2018frontierscellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xian-Si Zeng;Wen-Shuo Geng;Jin-Jing Jia;Lei Chen;Peng-Peng Zhang
Journal Frontiers in chemistry
Year 2018
DOI
10.3389/fnagi.2018.00109
URL
http://journal.frontiersin.org/article/10.3389/fnagi.2018.00109/full
Keywords
Parkinson disease neurodegeneration gene mutation neuropsychiatry biological psychiatry mechanismneurosciences

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