concise synthesis of catechin metabolites 5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (dhpv) in optically pure form and their stereochemical effects on skin wrinkle-reducing activities
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ID: 147525
2020
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Abstract
A concise and scalable synthetic route for optically pure (4S) and (4R)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexenol. Noticeably, the different skin wrinkle-reducing activities of each metabolite were revealed via our unique syntheses of DHPVs in an enantiomerically pure form.
| Reference Key |
hur2020moleculesconcise
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|---|---|
| Authors | ;Joonseong Hur;A-Ram Kim;Hyun Su Kim;Changjin Lim;Taewoo Kim;Tae-Aug Kim;Jaehoon Sim;Young-Ger Suh |
| Journal | Journal of ethnopharmacology |
| Year | 2020 |
| DOI |
10.3390/molecules25081970
|
| URL | |
| Keywords | Keywords not found |
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