tuberculosis in patients with haematological malignancies

Clicks: 136
ID: 147489
2014
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Abstract
Tuberculosis (TB) is an infectious disease that causes more than 1 million deaths worldwide every year. In addition, it is estimated that one third of the world population is infected with M. Tuberculosis in a latent state, which involves an eventual risk of progressing to active TB disease. Patients with immunodeficiencies, such as those suffering from haematological malignancies, have a greater risk of progressing to TB disease once infected. It is estimated that the Relative Risk of TB disease in patients with hematologic malignancies is 2-40 times that of general population. The diagnosis of TB in these patients is often difficult as they often present clinical characteristics that are distinct to those of patients without any other underlying disease. Mortality attributable to tuberculosis is higher. Therefore it is recommended to diagnose latent TB infection in order to offer a preventive therapy that could prevent the progression from a latent state to active TB disease. There are currently two methods for diagnosing latent TB infection: the Tuberculin Skin Test (TST) and the Interferon-Gamma Release Assays (IGRA). Due to the lack of sensitivity in patients with immunodeficient conditions, a combined TST-IGRA testing is probably the best way for latent TB diagnosis in order to gain sensitivity. Treatment of latent TB infection and TB disease should follow the general principles to that in general population.
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anibarro2014mediterraneantuberculosis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Luis Anibarro;Alberto Pena
Journal aktualʹnì pitannâ farmacevtičnoï ì medičnoï nauki ta praktiki
Year 2014
DOI
10.4084/mjhid.2014.026
URL
http://www.mjhid.org/index.php/mjhid/article/view/1363
Keywords
Diseases of the blood and blood-forming organs

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