mouse models in arrhythmogenic right ventricular cardiomyopathy

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ID: 147320
2012
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Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disorder characterized by fibrofatty replacement of cardiomyocytes. The cardinal manifestations are arrhythmias, sudden cardiac death and seldom heart failure. Mutations in genes encoding desmosomal proteins and their interaction partners have been implicated in the pathogenesis of ARVC and it is now widely accepted that ARVC is a disease caused by abnormal cell-cell adhesion due to defects in desmosomes. The mechanism(s) by which mutations in desmosomal proteins lead to fibro-fatty replacement remains to be fully elucidated. To this aim over the last 10 years different transgenic and targeted mouse models have been developed, these models and what they have taught us will be discussed in this review.
Reference Key
lodder2012frontiersmouse Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elisabeth M Lodder;Stefania eRizzo
Journal Journal of clinical and experimental dentistry
Year 2012
DOI
10.3389/fphys.2012.00221
URL
http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00221/full
Keywords
sudden death animal models

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