avaliação do perfil de dissolução de medicamentos utilizando-se espectroscopia eletrônica multivariada
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ID: 146968
2011
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Abstract
In this work the evaluation of the dissolution profile of captopril-hydrochlorothiazide and zidovudine-lamivudine associations were carried out by multivariate spectroscopic method. The models were developed by partial least square regression from 20 synthetic mixtures using mean-centered spectral data. The external validation was accomplished with 5 synthetic mixtures shown mean prevision error of about 1%. Good agreement was observed in the analyses of commercial drugs (content uniformity and dissolution profile), considering the results obtained by the standard chromatographic method, with prevision error lower than 10%.
| Reference Key |
santos2011qumicaavaliao
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|---|---|
| Authors | ;Juliana dos Santos;Gilcélia A Cordeiro;Noemi Nagata;Patricio Peralta-Zamora;Letícia Norma Carpentieri Rodrigues |
| Journal | greece and rome |
| Year | 2011 |
| DOI |
10.1590/S0100-40422011000900017
|
| URL | |
| Keywords | Keywords not found |
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