a comparative study of five mouse models of alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death

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ID: 146959
2011
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Abstract
Ectopic cell cycle events (CCEs) in postmitotic neurons link the neurodegenerative process in human Alzheimer's disease (AD) with the brain phenotype of transgenic mouse models with known familial AD genes. Most reports on the mouse models use the appearance of brain amyloid pathology as a key outcome measure. In the current paper, we focus on the induction of neurodegeneration using CCEs as markers for impending neuronal loss. We compare 5 mouse models of familial AD for the appearance of CCEs in subcortical regions—deep cerebellar nuclei, amygdala, locus coeruleus, hippocampus, and dorsal raphe. We find that the models differ in their CCE involvement as well as in the appearance of phosphorylated tau and amyloid deposition, suggesting that each model represents a different disease phenotype. Comparison with the pattern of neuron death in human AD suggests that each may represent a distinctly different disease model when used in preclinical trials.
Reference Key
li2011internationala Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Luming Li;Timmy Cheung;Jianmin Chen;Karl Herrup
Journal advanced biomedical research
Year 2011
DOI
10.4061/2011/171464
URL
http://dx.doi.org/10.4061/2011/171464
Keywords
neurosciences biological psychiatry neuropsychiatrygeriatrics

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