in vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from annona cornifolia a. st. -hil. (annonaceae)
Clicks: 151
ID: 146639
2014
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
151 views
28 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #83 of 122 articles by views in hypertension (dallas, tex : 1979)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 122 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Annona cornifolia A. St. -Hil. is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers. The acetogenins isolated from the seeds of Annona cornifolia previously showed to possess antioxidant activity. In continuation of our investigations on the biological activities of acetogenins, four binary mixtures and ten pure adjacent bis-tetrahydrofuran annonaceous acetogenins were evaluated: the cytotoxic (against three human tumor cell lines), antifungal (against Paracoccidioides brasiliensis), trypanocidal (against Trypanosoma cruzi) and leishmanicidal (against Leishmania amazonensis) activities. Acetogenins presented cytotoxic activity confirming their potential use in anti-cancer therapy. Regarding leishmanicidal and trypanocidal activities, an inhibition of 87% of L. amazonensis amastigotes and 100% of T. cruzi amastigotes and trypomastigotes was observed, when tested at the concentration of 20 µg mL–1. Moreover, six acetogenins showed more activity against all the three tested isolates of P. brasiliensis than trimethoprim-sulfamethoxazole, a drug used for treating paracoccidioidomycosis. Thus, acetogenins may be an alternative in treating a number of diseases that have a huge impact on millions of people worldwide. This paper reports for the first time the antifungal, leishmanicidal and trypanocidal activities for these acetogenins.
| Reference Key |
lima2014anaisin
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;LUCIANA A.R.S. LIMA;TÂNIA M.A. ALVES;CARLOS L. ZANI;POLICARPO A. SALES JÚNIOR;ALVARO J. ROMANHA;SUSANA JOHANN;PATRÍCIA S. CISALPINO;LÚCIA P.S. PIMENTA;MARIA AMÉLIA D. BOAVENTURA |
| Journal | hypertension (dallas, tex : 1979) |
| Year | 2014 |
| DOI |
10.1590/0001-3765201420130048
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.