inhibition of m/kv7 currents contributes to chloroquine-induced itch in mice

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ID: 146356
2020
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Abstract
M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channel activity contributes to generation of itch in mice. CQ enhances excitability of the primary sensory neurons through inhibiting M/Kv7 potassium currents in a Ca2+ influx-dependent manner. Specific M/Kv7 channel opener retigabine (RTG) or tannic acid (TA) not only reverses the CQ-induced enhancement of neuronal excitability but also suppresses the CQ-induced itch behavior. Systemic application of RTG or TA also significantly inhibits the itch behavior induced by a variety of pruritogens. Taken together, our findings provide novel insight into the molecular basis of CQ-induced itch sensation in mammals that can be applied to the development of strategies to mitigate itch behavior.
Reference Key
zhang2020frontiersinhibition1 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dong Zhang;Dong Zhang;Dong Zhang;Dong Zhang;Dong Zhang;Hongchao Men;Hongchao Men;Hongchao Men;Hongchao Men;Hongchao Men;Ludi Zhang;Ludi Zhang;Ludi Zhang;Ludi Zhang;Xiangxin Gao;Xiangxin Gao;Xiangxin Gao;Xiangxin Gao;Jingjing Wang;Jingjing Wang;Jingjing Wang;Jingjing Wang;Leying Li;Leying Li;Leying Li;Leying Li;Qiaoying Zhu;Qiaoying Zhu;Qiaoying Zhu;Qiaoying Zhu;Hailin Zhang;Hailin Zhang;Hailin Zhang;Hailin Zhang;Zhanfeng Jia;Zhanfeng Jia;Zhanfeng Jia;Zhanfeng Jia
Journal international journal of nanomedicine
Year 2020
DOI
10.3389/fnmol.2020.00105
URL
https://www.frontiersin.org/article/10.3389/fnmol.2020.00105/full
Keywords
inhibition chloroquine neuropsychiatry biological psychiatry

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